APPLY NOW

 

The applications for the PhD position in the laboratory of Dr. Hind Medyouf at the Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus (Frankfurt, Germany) are now closed!

Thank you to all candidates for applying! We will now evaluate the applications and communicate the interview dates to successful candidates.

WHAT WE OFFER

A highly stimulating and clinically relevant project in an inspiring international research team within an interdisciplinary network of scientists, clinicians and industrial partners. 

As part of the INTERCEPT-MDS network, the PhD fellow participates in organized training courses, networking events and expands expertise through stays in the laboratories of other network members (see more info below). The institute is located in the heart of Frankfurt providing a very stimulating, friendly and international environment. The working language is English.

Full-time employment contract with a competitive salary (following the MSCA regulations for Early Stage Researchers

The INTERCEPT-MDS network:
SCIENTIFIC EXCELLENCE AND PERSONAL DEVELOPMENT

The highly complementary composition of the INTERCEPT-MDS network will provide all the key expertise and infrastructure to support the scientific excellence of the PhD candidate.

Experts from two sectors (academia and industry) and two research environments (clinical and basic) across Europe will offer a unique multidisciplinary and multisectoral training opportunity in the novel field of disease interception.

Successful applicants will be enrolled in a PhD programme and will receive a structured training programme consisting of soft skill courses, targeted workshops, conferences, retreats, social events and networking.

In addition, our PhD candidates will carry out secondments in other European institutions within the network to provide the needed interactions to achieve research and training excellence, and improve their future career perspectives in academia and the private sector.

VACANCIES LIST

We have the following position available for a highly motivated PhD candidate:

PhD Project 9: Exploiting 3D organotypic niche models to dissect the cellular crosstalk between niche and haematopoietic stem/progenitor cells (HSPCs) in myelodysplastic syndromes (MDS).

The scientific project builds on recent developments in the Medyouf lab and will use tissue engineering approaches to explore the biology of human myelodysplastic syndromes (MDS), in a fully human setting. MDS is a heterogenous group of pre-leukemic diseases where pre-malignant stem cells show a great dependency on their surrounding niche cells (Medyouf, Cell Stem Cell, 2014; Medyouf, Blood, 2017). The goal of the PhD candidate will be to dissect the molecular mechanisms and cellular interactions that underpin this dependency and leverage the gained knowledge for disease interception, before transformation into acute leukemia. The PhD candidate will initially optimize the recently established 3D human organotypic marrow environments (3DHOMEs) to increase throughput and standardization, two essential features that will allow the PhD candidate to conduct screens. Results obtained from the 3DHOMEs will be validated using established patient-derived xenograft models.

Host institution: Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus. Frankfurt, Germany.

Supervisor: Hind Medyouf (visit website here).

Envisioned secondments: GenomeScan B.V. (The Netherlands) and University of Bergen (Norway). To further broaden the expertise of the PhD candidate and support the project, two secondments (stays in collaborating laboratories within the network) of 3 months will be offered as an integral part of the PhD project.

ELIGIBILITY CRITERIA

Applicants can be of any nationality and must fulfil the following conditions:

• Not have resided or carried out their main activity (work, studies, etc.) in Germany for more than 12 months in the 3 years immediately prior to their recruitment.

• Be in the first 4 years (full-time equivalent research experience) of their research careers and not have been awarded a doctoral degree at the date of recruitment.

• Have a master’s degree relevant to the chosen position or an equivalent qualification that would entitle them to embark on a doctorate by the time they are recruited. Applications are welcome from candidates who are currently finishing their master studies (state the expected defense date in the application).

• Have a high level of proficiency in written and spoken English.

Successful candidates will have a strong interest in tissue engineering or translational research. Applicants with solid background in computational biology will be given priority. 

Having an interest on outreach activities and public engagement will be considered a plus.

APPLICATION PROCESS

Download the Full details document to read the full description about the application process and the required documents.

Eligible applications will be ranked on the basis of CVs and merits by a selection committee. The 3 top candidates for the position will be invited for a virtual interview where the final candidate will be selected.

Applicants with a positive evaluation but not selected will be included on a reserve list to cover eventual future positions and might be contacted at a later stage. 

TIMELINE

Application deadline
Deadline extended to 12 May 2022 at midnight (CEST)

Tentative start of fellowship
By June 2022