Ecem Kirkiz participates with a poster to EHA2024

In her poster, Ecem presents her work on the regulators influencing the stability of NUP98 fusion oncoproteins. NUP98-rearranged pediatric leukemias pose significant treatment challenges, necessitating targeted therapeutic approaches.

Through comprehensive analysis, the study identified 87 factors potentially involved in NUP98 fusion oncoprotein stability, with a particular focus on the ubiquitin proteasome system (UPS) and E3 ligases. Experimental validation using CRISPR/Cas9 screens and inhibitor assays revealed key roles for proteasome subunits and specific E3 ligases in regulating NUP98::KDM5A fusion oncoprotein stability.

These findings shed light on previously unexplored mechanisms controlling NUP98 fusion oncoprotein homeostasis and offer promising prospects for developing targeted therapies to improve patient outcomes in NUP98-r leukemia.

For more information, follow the link: EHA Library – The official digital education library of European Hematology Association (EHA) (ehaweb.org)