Priyansh Srivastava participates with a poster to EHA2024

In his poster, Priyansh presents how he employs Trajectory Inference (TI) Analysis to model cell development in the bone marrow microenvironment, using “Pseudotime” to track gene expression changes.

By introducing “Pathway-Metagenes,” which capture pathway activity over time, the research provides a more nuanced understanding of cellular function transitions compared to traditional gene lists.

Validated with CD34+ hematopoietic stem and progenitor cells (HSPCs), this method highlights significant functional shifts, such as the decrease in WNT-Signaling pathway activity crucial for HSC maintenance, offering new insights for therapeutic strategies in myelodysplastic syndromes.

For more information, follow the link: EHA Library – The official digital education library of European Hematology Association (EHA) (ehaweb.org)