ESR projects

Research project

Cross-talk between single haematopoietic stem/progenitor cells and bone marrow niche in myelodysplastic syndromes and secondary-type acute myeloid leukaemia (WP1)

Rationale and objectives

In disease and aging, the stroma cells of the bone marrow are epigenetically altered and support less healthy haematopoietic stem/progenitor cells (HSPCs). Whether this decline is cell intrinsic or instructed by mutated HSPCs is not fully understood.

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Our objectives are:

• To analyze on the single-cell level the reciprocal influence of HSPCs and stroma cells on gene transcription.

• To identify and validate gene signatures correlating with MDS and normal aging.

• To functionally test involved key pathways in vitro and in vivo using CRISPR/Cas9-engineered cells.

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Envisioned secondments

GenomeScan B.V. (The Netherlands, 3 months), Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus (Germany, 3 months).

PhD programme

PhD in Experimental Medicine, TUM graduate School (TUM-GS), Germany.