ESR projects

Research project

Understanding and reverting the epigenetic reprogramming of bone marrow stroma cells in myelodysplastic syndromes (WP2)

Rationale and objectives

Epigenetic changes contribute to a switch in the preferential support of myelodysplastic syndromes (MDS) and secondary-type acute myeloid leukaemia (sAML) haematopoietic stem cell/progenitors (HSPCs) over healthy HSPCs by bone marrow (BM) stroma cells.

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Our objectives are:

• To establish a three-component co-culture system of disease HSPCs, healthy HSPCs and stroma cells.

• To identify chromatin regulators in stroma cells that sustain a transcriptional program favoring disease HSPC support.

• To understand how most-disease relevant chromatin regulators exert their function.

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Envisioned secondments

Klinikum rechts der Isar der TU München and Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus (Germany, 3 months). Depending on the project development: Aelian Bio (Austria, 1 month).

PhD programme

PhD in Cell Biology, Autonomous University of Barcelona (UAB), Spain.