Individual
ESR projects

Research project

Targeted inhibition of the NUP98-NSD1 fusion oncogene in myelodysplastic syndromes and acute myeloid leukaemia models by NSD1 inhibitors (WP2)

Rationale and objectives

We will analyze the efficiency of epigenetic drugs as a mechanism to decrease aberrant histone methylation activity in myelodysplastic syndrome (MDS) and secondary Acute Myeloid Leukaemia (sAML) driven by the fusion protein of NUP98 and the histone methylase NSD1.

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Our tasks are:

• To determine the effect of NSD1 inhibitors in murine and human cells with NUP98-NSD1 on the level of cell biology.

• To study the genome-wide patterns of histone modifications before and after the treatment in order to identify target loci.

• To understand the impact of NSD1 inhibition on intercellular heterogeneity by perform scRNA-seq.

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Envisioned secondments

Veterinärmedizinische Universität Wien (Austria, 4 months). Depending on the project development: Aelian Bio (Austria, 1 month).

PhD programme

PhD in Cell Biology, Autonomous University of Barcelona (UAB), Spain.