EARLY STAGE
RESEARCHERS

Early researcher

Shubhra A. Bhattacharya

Background

 

My B.Sc (Bachelor in Sciences) was in the field of Biochemistry at Bangalore University, India. I then double majored in Bioinformatics and Biotechnology in Institute of Bioinformatics and Applied Biotechnology, Bengaluru. I was a junior research fellow at National Center for biological science, Bengaluru from 2019 to 2021, wherein my research was to understand key genes and pathways in brain disorders: namely bipolar disorder, schizophrenia, depression, substance abuse disorders and obsessive-compulsive disorder.

My research activity included the analysis of high volumes of  next generation sequencing data namely: Whole Exome and Whole Genome sequencing, RNA-Sequencing data. By wranglinh datasets and public data repositories using R and python and active discussions with clinicians and psychiatrists I developed up to date analysis methods for sequencing data.

Research

My project aims to understand the role of clonal hematopoiesis of indeterminate potential (CHIP) mutations in myelodysplastic syndromes (MDS) and how these mutations have an underlying role in transcription machinery of the cell.

Not every individual with CHIP mutations develops MDS; this is a point of interest in the project to understand how CHIP influences MDS in patients who are developing the disease as compared to those who do not. I would like to study this using patient cohorts with the disorder. Since the dataset involves an abundance of information such as transcriptomic data, variant data and clinical data, I would like to develop stratification models by combining genomic and clinical features by the analysis of large datasets from MDS patients and test the findings in experimental setup.