PROJECT
SUPERVISORS
Project Supervisor
Roberto Malinverni
Background
I started my scientific career studying molecular biology at the University of Pavia. I obtained my degree by spending two years of internship at the forensic hematology laboratory studying the haplogroups of the Y chromosome.
I obtained my doctorate at the University of Milan, supervised by Dr. Elisabetta Giuffra and Prof. Cristina Battaglia, studying the response of porcine alveolar macrophages to the response of the PRRSV coronavirus. During this period my interest in bioinformatics has consolidated.
Since 2011 I have been working as at bioinformatician in the laboratory of Dr. Marcus Buschbeck in Badalona before the Institute of Predictive and Personalized Medicine of Cancer (IMPPC) and currently at Josep Carreras Leukaemia Research Institute (IJC). I am mainly working in the study of the histone variant MacroH2A, and in the development of pipelines and bioinformatics tools.
Research
My main research interests are on the one hand the study of chromatin, in particular the association between histone modifications and conformation and on the other hand the study of the mechanisms that lead from Myelodysplastic syndromes (MDS) to secondary Acute Myeloid Leukaemia (sAML).
The INTERCEPT-MDS ITN gives me the possibility to combine these interests in a project aimed at studying how mutations, in particular chromatin modifiers, act at the level of gene expression and chromatin structure during the different stages leading to sAML.
Publications
Cabezón M*, Malinverni R* et al. Different methylation signatures at diagnosis in patients with high-risk myelodysplastic syndromes and secondary acute myeloid leukemia predict azacitidine response and longer survival. Clin Epigenetics. 2021
Douet J et al. MacroH2A histone variants maintain nuclear organization and heterochromatin architecture. J Cell Sci. 2017
Gel B et al. regioneR: an R/Bioconductor package for the association analysis of genomic regions based on permutation tests. Bioinformatics. 2016