Individual ESR projects

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Impact of clonal haematopoiesis with indeterminate potential mutations on transcription in single-cells (WP1)

Josep Carreras Leukaemia Research Institute, Spain

Marcus Buschbeck, Roberto Malinverni

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Dissect haematopoietic stem/progenitor cells-bone marrow niche interaction on a single cell level in low risk myelodysplastic syndromes (WP1)

Erasmus Medical Center, The Netherlands

Rebekka Schneider, Hélène Gleitz

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Cross-talk between single haematopoietic stem/progenitor cells and bone marrow niche in myelodysplastic syndromes and secondary-type acute myeloid leukaemia (WP1)

Klinikum rechts der Isar der TU München, Germany

Katharina Götze

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Phenotypic heterogeneity of myelodysplastic cells and influence of epigenetic therapies (WP1)

Institut national de la sante et de la recherche medicale, France

Alexandre Puissant, Raphael Itzykson

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Understanding and reverting the epigenetic reprogramming of bone marrow stroma cells in myelodysplastic syndromes (WP2)

Josep Carreras Leukaemia Research Institute, Spain

Marcus Buschbeck, René Winkler

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Targeted inhibition of the NUP98-NSD1 fusion oncogene in myelodysplastic syndromes and acute myeloid leukaemia models by NSD1 inhibitors (WP2)

Josep Carreras Leukaemia Research Institute, Spain

Manel Esteller, María Berdasco

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Functional identification of effectors of fusion proteins that drive secondary-type acute myeloid leukaemia (WP2)

Veterinärmedizinische Universität Wien, Austria

Florian Grebien

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DNA methylation as determinant of myelodysplastic syndromes treatment with hypomethylating agents (WP2)

Università degli Studi di Firenze, Italy

Valeria Santini

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Exploiting 3D organotypic niche models to dissect the cellular crosstalk between niche and haematopoietic stem/progenitor cells in human myelodysplastic syndromes (WP3)

Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Germany

Hind Medyouf

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Enhancing the informative value of bulk bone marrow RNA-seq by inferring cell-type contributions (WP3)

MLL Munich Leukemia Laboratory, Germany

Torsten Haferlach, Wencke Walter

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Development of pre-clinical patient-derived xenograft models of myelodysplastic syndromes (WP3)

University of Bergen, Norway

Emmet McCormack

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Development of methods for the functional analysis of single cell RNA-seq data (WP3)

BioBam Bioinformatics, Spain

Stefan Götz

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