Individual ESR projects

 

Our 12 Early Stage Researchers (ESRs) carry out individual research projects at their host institutions under the supervision of our network members. Each project belongs to one of our three dedicated research work packages (WPs) to address our scientific objectives.

The ESRs will undertake secondments to institutions belonging to other sectors and environments during the development of the project, and all of them are enrolled in the PhD programme of one of the participating organisations of the network.

Impact of clonal haematopoiesis with indeterminate potential mutations on transcription in single-cells (WP1)

Josep Carreras Leukaemia Research Institute, Spain

Shubhra A. Bhattacharya

Marcus Buschbeck, Roberto Malinverni

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Dissect haematopoietic stem/progenitor cells-bone marrow niche interaction on a single cell level in low risk myelodysplastic syndromes (WP1)

Erasmus Medical Center, The Netherlands

Stephani Schmitz

Rebekka Schneider, Hélène Gleitz

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Dissecting the cellular crosstalk between the bone marrow microenvironment and hematopoietic stem/progenitor cells in clonal hematopoiesis of indeterminate potential, myelodysplastic syndromes and secondary acute myeloid leukaemia (WP1)

Klinikum rechts der Isar der TU München, Germany

Anna Navarro i Figueredo

Katharina Götze

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Phenotypic heterogeneity of myelodysplastic cells and influence of epigenetic therapies (WP1)

Institut national de la sante et de la recherche medicale, France

Giuseppe Di Feo

Alexandre Puissant, Raphael Itzykson

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Understanding and reverting the epigenetic reprogramming of bone marrow stroma cells in myelodysplastic syndromes (WP2)

Josep Carreras Leukaemia Research Institute, Spain

Eve Dias

Marcus Buschbeck, René Winkler

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Targeted inhibition of the NUP98-NSD1 and NUP98-KDM5A fusion oncogenes in myelodysplastic syndromes and acute myeloid leukaemia models by NSD1 and KDM5A inhibitors (WP2)

Josep Carreras Leukaemia Research Institute, Spain

James Heald

Manel Esteller, María Berdasco

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Functional identification of effectors of fusion proteins that drive secondary-type acute myeloid leukaemia (WP2)

Veterinärmedizinische Universität Wien, Austria

Ecem Kirkiz

Florian Grebien

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DNA methylation as determinant of myelodysplastic syndromes treatment with hypomethylating agents (WP2)

Università degli Studi di Firenze, Italy

Sven De Pourcq

Valeria Santini

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Exploiting 3D organotypic niche models to dissect the cellular crosstalk between niche and haematopoietic stem/progenitor cells in human myelodysplastic syndromes (WP3)

Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Germany

Hind Medyouf

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Enhancing the informative value of bulk bone marrow RNA-seq by inferring cell-type contributions (WP3)

MLL Munich Leukemia Laboratory, Germany

Maki Sakuma

Torsten Haferlach, Wencke Walter

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Development of pre-clinical patient-derived xenograft models of myelodysplastic syndromes (WP3)

University of Bergen, Norway

Ângela Sofia Gerós Mesquita

Emmet McCormack

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Development of methods for the functional analysis of single-cell RNA-seq data (WP3)

BioBam Bioinformatics, Spain

Priyansh Srivastava

Ana Conesa, Stefan Götz

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